BDBM500635 7-((5-(4- hydroxypiper- idin-1-yl)-4- methoxypyridin- 2-yl)amino)- 4-(1-methyl- 1H-pyrrolo[2.3- b]pyridin-4- yl)isoindolin- 1-one::US11021481, Compound I-295::US11078201, Compound I-295::US11548890, Compound I-295

SMILES COc1cc(Nc2ccc(c3CNC(=O)c23)-c2ccnc3n(C)ccc23)ncc1N1CCC(O)CC1

InChI Key InChIKey=NDKUATGWSPPWKR-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500635   

LigandPNGBDBM500635(US11021481, Compound I-295 | 7-((5-(4- hydroxypipe...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500635(US11021481, Compound I-295 | 7-((5-(4- hydroxypipe...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500635(US11021481, Compound I-295 | 7-((5-(4- hydroxypipe...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500635(US11021481, Compound I-295 | 7-((5-(4- hydroxypipe...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500635(US11021481, Compound I-295 | 7-((5-(4- hydroxypipe...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent