BDBM500639 7-((5-(2-oxa- 7-azaspiro[3,5] nonan-7- yl)pyridin-2- yl)amino)-4- (1-methyl-1H- pyrrolo[2,3- blpyridin-4- yl)isoindolin- 1-one::US11021481, Compound I-299::US11078201, Compound I-299::US11548890, Compound I-299

SMILES Cn1ccc2c(ccnc12)-c1ccc(Nc2ccc(cn2)N2CCC3(COC3)CC2)c2C(=O)NCc12

InChI Key InChIKey=REJOAKMPTGWOOC-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500639   

LigandPNGBDBM500639(US11021481, Compound I-299 | 7-((5-(2-oxa- 7-azasp...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500639(US11021481, Compound I-299 | 7-((5-(2-oxa- 7-azasp...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500639(US11021481, Compound I-299 | 7-((5-(2-oxa- 7-azasp...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500639(US11021481, Compound I-299 | 7-((5-(2-oxa- 7-azasp...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500639(US11021481, Compound I-299 | 7-((5-(2-oxa- 7-azasp...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent