BDBM50064045 7-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[4',3':4,5]furo[2,3-d]pyrimidine-2,4-diamine::CHEMBL287579

SMILES Nc1nc(N)c2c3CCN(Cc4ccc(Cl)cc4Cl)Cc3oc2n1

InChI Key InChIKey=GUXRAMSKYHJDIN-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50064045   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064045(7-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50: 1.31E+4nMAssay Description:Inhibition of Toxoplasma gondii Dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064045(7-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50: 2.26E+4nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Mycobacterium avium)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064045(7-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibitory concentration was evaluated against CCRF-CEM Dihydrofolate reductase enzyme in Mycobacterium avium.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50064045(7-(2,4-Dichloro-benzyl)-5,6,7,8-tetrahydro-pyrido[...)
Affinity DataIC50: 5.09E+4nMAssay Description:Inhibition of Dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed