BDBM500643 (S)-7-((5-(4- hydroxy- piperidin-1- yl)pyridin-2- yl)amino)-4- (7-methyl- 5,6,7.8- tetrahydroimi- dazo[1,2- a]pyridin-3- yl)isoindolin- 1-one::US11021481, Compound I-303::US11078201, Compound I-303::US11548890, Compound I-303

SMILES C[C@H]1CCn2c(C1)ncc2-c1ccc(Nc2ccc(cn2)N2CCC(O)CC2)c2C(=O)NCc12

InChI Key InChIKey=FTFZTKNDCUIQFZ-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500643   

LigandPNGBDBM500643(US11021481, Compound I-303 | (S)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500643(US11021481, Compound I-303 | (S)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500643(US11021481, Compound I-303 | (S)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500643(US11021481, Compound I-303 | (S)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500643(US11021481, Compound I-303 | (S)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent