BDBM500651 (R)-7-((5-(3-(2- hydroxypropan- 2-yl)piperidin-1- yl)pyridin-2- yl)amino)-4- (imidazo[1,2- a]pyrazin-3- yl)isoindolin- 1-one::US11021481, Compound I-311::US11078201, Compound I-311::US11548890, Compound I-311

SMILES CC(C)(O)[C@@H]1CCCN(C1)c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cnccn23)nc1

InChI Key InChIKey=PXJXYDFYZNSLKO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500651   

LigandPNGBDBM500651(US11021481, Compound I-311 | (R)-7-((5-(3-(2- hydr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500651(US11021481, Compound I-311 | (R)-7-((5-(3-(2- hydr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500651(US11021481, Compound I-311 | (R)-7-((5-(3-(2- hydr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500651(US11021481, Compound I-311 | (R)-7-((5-(3-(2- hydr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500651(US11021481, Compound I-311 | (R)-7-((5-(3-(2- hydr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent