BDBM500654 (S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- methylmorpho- lino)pyridin-2- yl)amino)isoin- dolin-1-one::US11021481, Compound I-314::US11021481, Compound I-322::US11078201, Compound I-322::US11548890, Compound I-322

SMILES C[C@H]1COCCN1c1ccc(Nc2ccc(c3CNC(=O)c23)-c2cnc3cnccn23)nc1

InChI Key InChIKey=OBGFJUWSVZRMFS-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 500654   

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500654((S)-4- (imidazo[1,2- a]pyrazin-3- yl)-7-((5-(3- me...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent