BDBM500657 (R)-7-((5-(4- hydroxy- piperidin-1- yl)pyridin-2- yl)amino)-4- (imidazo[1,2- a]pyridin-3- yl)-3-methylisoindo- lin-1-one::US11021481, Compound I-317::US11078201, Compound I-317::US11548890, Compound I-317

SMILES C[C@H]1NC(=O)c2c1c(ccc2Nc1ccc(cn1)N1CCC(O)CC1)-c1cnc2ccccn12

InChI Key InChIKey=SSEZGRFAKJCMQA-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500657   

LigandPNGBDBM500657(US11021481, Compound I-317 | (R)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500657(US11021481, Compound I-317 | (R)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500657(US11021481, Compound I-317 | (R)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500657(US11021481, Compound I-317 | (R)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500657(US11021481, Compound I-317 | (R)-7-((5-(4- hydroxy...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent