BDBM500658 4-(imidazo[1,2- a]pyrazin-3- yl)-7-((5- ((3aR,6aS)- tetrahydro-1H- furo[3,4-c]pyrrol- 5(3H)-yl)pyridin-2- yl)amino)isoin- dolin-1-one::US11021481, Compound I-318::US11078201, Compound I-318::US11548890, Compound I-318

SMILES O=C1NCc2c1c(Nc1ccc(cn1)N1C[C@@H]3COC[C@@H]3C1)ccc2-c1cnc2cnccn12

InChI Key InChIKey=OLLXOIOWQTYNAO-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500658   

LigandPNGBDBM500658(US11021481, Compound I-318 | 4-(imidazo[1,2- a]pyr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2021
Entry Details
US Patent

LigandPNGBDBM500658(US11021481, Compound I-318 | 4-(imidazo[1,2- a]pyr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent

LigandPNGBDBM500658(US11021481, Compound I-318 | 4-(imidazo[1,2- a]pyr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/16/2022
Entry Details
US Patent

LigandPNGBDBM500658(US11021481, Compound I-318 | 4-(imidazo[1,2- a]pyr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/5/2023
Entry Details
US Patent

LigandPNGBDBM500658(US11021481, Compound I-318 | 4-(imidazo[1,2- a]pyr...)
Affinity DataIC50: 100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/29/2021
Entry Details
US Patent