BDBM50066496 CHEMBL115804::N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazoline-2,4,6-triamine

SMILES COc1ccc(CN(C)c2ccc3nc(N)nc(N)c3c2)c(OC)c1

InChI Key InChIKey=QABCVDFLEMLVBN-UHFFFAOYSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50066496   

TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 3.90nMAssay Description:Inhibition of recombinant Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Escherichia coli)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against recombinant Dihydrofolate reductase from Escherichia coli (ecDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 39nMAssay Description:Inhibition of Toxoplasma gondii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 39nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Toxoplasma gondii (tgDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 43nMAssay Description:Inhibitory activity against Dihydrofolate reductase from rat liver (rlDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Rat)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 43nMAssay Description:Inhibition of rat liver dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Human)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 100nMAssay Description:Inhibition of Pneumocystis carinii dihydrofolate reductaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 100nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Pneumocystis carinii (pcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50066496(N*6*-(2,4-Dimethoxy-benzyl)-N*6*-methyl-quinazolin...)
Affinity DataIC50: 120nMAssay Description:Inhibitory activity against Dihydrofolate reductase from Lactobacillus casei (lcDHFR)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed