BDBM50067933 5-(((2S,3S)-2-(3,5-bis(trifluoromethyl)benzyloxy)-3-(4-fluorophenyl)morpholino)methyl)-2H-1,2,4-triazol-3(4H)-one::5-[(2S,3S)-2-(3,5-Bis-trifluoromethyl-benzyloxy)-3-(4-fluoro-phenyl)-morpholin-4-ylmethyl]-2,4-dihydro-[1,2,4]triazol-3-one::CHEMBL140745

SMILES Fc1ccc(cc1)[C@H]1[C@@H](OCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)OCCN1Cc1n[nH]c(=O)[nH]1

InChI Key InChIKey=FYADPUQVZFJTEM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50067933   

TargetSubstance-P receptor(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067933(5-[(2S,3S)-2-(3,5-Bis-trifluoromethyl-benzyloxy)-3...)
Affinity DataIC50: 0.0700nMAssay Description:Antagonist activity at human neurokinin receptor 1 assessed as inhibition of 125I-substance P binding to receptor by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2024
Entry Details
PubMed
TargetSubstance-P receptor(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067933(5-[(2S,3S)-2-(3,5-Bis-trifluoromethyl-benzyloxy)-3...)
Affinity DataIC50: 0.0700nMAssay Description:Displacement of [125I]-labeled SP from the human Tachykinin receptor 1 expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSubstance-P receptor(Human)
Xenon Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50067933(5-[(2S,3S)-2-(3,5-Bis-trifluoromethyl-benzyloxy)-3...)
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of NK1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed