BDBM50070320 CHEMBL3408278::US9718800, 7.01b

SMILES C[C@@H](N(C)c1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N1CCC(O)CC1

InChI Key InChIKey=UOZWDNWNBWHNIU-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50070320   

LigandPNGBDBM50070320(CHEMBL3408278 | US9718800, 7.01b)
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50070320(CHEMBL3408278 | US9718800, 7.01b)
Affinity DataIC50: 12nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50070320(CHEMBL3408278 | US9718800, 7.01b)
Affinity DataIC50: 82nMAssay Description:Inhibition of human recombinant PI3Kdelta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50070320(CHEMBL3408278 | US9718800, 7.01b)
Affinity DataIC50: 370nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50070320(CHEMBL3408278 | US9718800, 7.01b)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of human recombinant PI3Kgamma using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/20/2016
Entry Details Article
PubMed
LigandPNGBDBM50070320(CHEMBL3408278 | US9718800, 7.01b)
Affinity DataIC50: 4.32E+3nMT: 2°CAssay Description:Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2018
Entry Details
US Patent