BDBM50070322 CHEMBL3408248::US9718800, 3.06b

SMILES C[C@@H](Nc1cc(F)cc(F)c1)c1cc(cc2c1oc(cc2=O)N1CCOCC1)C(=O)N(C)C

InChI Key InChIKey=LMJFJIDLEAWOQJ-CQSZACIVSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50070322   

LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  675nMAssay Description:Inhibition of human recombinant PI3Kgamma using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant PI3Kdelta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  3nMAssay Description:Inhibition of PI3Kbeta in PTEN-null human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant PI3Kbeta using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant PI3Kalpha using PIP2 by Kinase-Glo Plus assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of human full length p110gamma using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  2nMT: 2°CAssay Description:Compounds in 100% DMSO were added to assay plates by acoustic dispensing. PI3Kβ was added in a Tris buffer (50 mM Tris pH7.4, 0.05% CHAPS, 2.1 m...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  3nMAssay Description:Inhibition of recombinant human full-length N-terminal His6-tagged p110beta/human recombinant full-length untagged p85alpha expressed in baculovirus ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  450nMAssay Description:Inhibition of human full length p110alpha/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  36nMAssay Description:Inhibition of human p110delta catalytic subunit/p85alpha using PIP2 as substrate after 30 mins in presence of ATP at 2xKm concentration by TR-FRET as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50070322(CHEMBL3408248 | US9718800, 3.06b)
Affinity DataIC50:  17nMAssay Description:Inhibition of PI3Kdelta in human Jeko B cells assessed as inhibition of Akt phosphorylation after 2 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed