BDBM50070536 1-(5-Chloro-pyridin-2-yl)-3-[(1R,2R)-2-(3-ethoxy-2,6-difluoro-phenyl)-cyclopropyl]-urea::CHEMBL37024

SMILES CCOc1ccc(F)c([C@H]2C[C@H]2NC(=O)Nc2ccc(Cl)cn2)c1F

InChI Key InChIKey=QLRFOQAJDSEUSU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50070536   

TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070536(1-(5-Chloro-pyridin-2-yl)-3-[(1R,2R)-2-(3-ethoxy-2...)
Affinity DataIC50: 1.5nMAssay Description:Inhibitory effect on wild type HIV- 1 reverse transcriptase using rCdG as template and dGTP as substrate.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070536(1-(5-Chloro-pyridin-2-yl)-3-[(1R,2R)-2-(3-ethoxy-2...)
Affinity DataIC50: 15nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Tyr 181 to Cys 181 (clone 90)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetReverse transcriptase/RNaseH(Human immunodeficiency virus type 1)
Medivir

Curated by ChEMBL
LigandPNGBDBM50070536(1-(5-Chloro-pyridin-2-yl)-3-[(1R,2R)-2-(3-ethoxy-2...)
Affinity DataIC50: 80nMAssay Description:Inhibitory effect on recombinant HIV- 1 reverse transcriptase which has a mutation Leu 100 to Ile 100 (clone 118)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed