BDBM50075751 4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-yl]-benzonitrile::CHEMBL158989

SMILES Fc1ccc(cc1)-c1cc([nH]c1-c1ccncc1)-c1ccc(cc1)C#N

InChI Key InChIKey=NVWTWHYQHRAFNN-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50075751   

TargetGlucagon receptor(Mus musculus)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075751(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50:  230nMAssay Description:Binding affinity towards glucagon receptor determined by reduction in binding of [125I]-glucagon to the murine glucagon receptor (GGR) expressed on C...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075751(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50:  140nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075751(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50:  50nMAssay Description:Antagonist activity at human glucagon receptorMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlucagon receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075751(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50:  4.90E+3nMAssay Description:Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50075751(4-[4-(4-Fluoro-phenyl)-5-pyridin-4-yl-1H-pyrrol-2-...)
Affinity DataIC50:  50nMAssay Description:Inhibitory activity against p38-alpha kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed