BDBM50078681 CHEMBL3415456

SMILES ONC(=O)c1ccc(NC2CCN(C2=O)c2ccccc2Cl)cc1

InChI Key InChIKey=UFWROTGTGBWIJQ-UHFFFAOYSA-N

Data  3 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50078681   

TargetHistone deacetylase 8(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078681(CHEMBL3415456)
Affinity DataIC50: 150nMAssay Description:Inhibition of HDAC8 (unknown origin) using RHK(Ac)K(Ac)AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078681(CHEMBL3415456)
Affinity DataIC50: 360nMAssay Description:Inhibition of HDAC6 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078681(CHEMBL3415456)
Affinity DataEC50:  6.70E+3nMAssay Description:Inhibition of HDAC6 in human A549 cells assessed as induction of tubulin acetylation after 17 to 18 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Roche Innovation Center Shanghai

Curated by ChEMBL
LigandPNGBDBM50078681(CHEMBL3415456)
Affinity DataIC50: 2.18E+4nMAssay Description:Inhibition of HDAC1 (unknown origin) using RHKK(Ac)AMC as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/27/2016
Entry Details Article
PubMed