BDBM50081643 CHEMBL3422240::US9260455, 2

SMILES [H][C@@]12C[C@H](COC)OC[C@@]1(N=C(N)S[C@@H]2C)c1ccc(F)cc1F

InChI Key InChIKey=VWZBYKQRKVQAQK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50081643   

TargetIsoform D of Beta-secretase 1 (BACE-I-432)(Human)
Pfizer

US Patent
LigandPNGBDBM50081643(CHEMBL3422240 | US9260455, 2)
Affinity DataIC50: 737nMpH: 4.5 T: 2°CAssay Description:A synthetic APP substrate that can be cleaved by beta-secretase having N-terminal biotin and made fluorescent by the covalent attachment of Oregon Gr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
US Patent

TargetBeta-secretase 1(Human)
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50081643(CHEMBL3422240 | US9260455, 2)
Affinity DataIC50: 800nMAssay Description:Inhibition of BACE1 in human H4 cells overexpressing wild type human APP695 assessed as colorimetric reaction by Whole cell assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/30/2016
Entry Details Article
PubMed
TargetBeta-secretase 2(Human)
Pfizer

US Patent
LigandPNGBDBM50081643(CHEMBL3422240 | US9260455, 2)
Affinity DataIC50: 2.31E+3nMpH: 4.5 T: 2°CAssay Description:This assay measures the inhibition of the BACE2 enzyme as it cleaves a non-native peptide. A synthetic substrate that can be cleaved by BACE2 having ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2017
Entry Details
US Patent