BDBM50082713 5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2-thiophen-2-yl-pentanenitrile::CHEMBL346205

SMILES OC1(CCN(CCCC(C#N)c2cccs2)CC1)c1ccc(Cl)cc1

InChI Key InChIKey=CMFKIUAFSUSUDX-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50082713   

TargetC-C chemokine receptor type 1(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50082713(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Affinity DataKi:  128nMAssay Description:Inhibition of [125I]-MIP-1 alpha binding to recombinant human C-C chemokine receptor type 1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 1(Human)
Berlex Biosciences

Curated by ChEMBL
LigandPNGBDBM50082713(5-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-2...)
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of MIP-1-alpha-induced intracellular calcium mobilization in HEK293 cells expressing human CCR1 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/13/2012
Entry Details Article
PubMed