BDBM50084037 CHEMBL3425672

SMILES COc1cc(ccc1Nc1ncc(Cl)c(Oc2cccc(NC(=O)\C=C\C3CC3)c2)n1)N1CCN(C)CC1

InChI Key InChIKey=NABVLMHESOKZLJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50084037   

TargetEpidermal growth factor receptor(Human)
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50084037(CHEMBL3425672)
Affinity DataIC50: 830nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) T790M/L858R mutant expressed in Sf9 cells pre-incubated fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50084037(CHEMBL3425672)
Affinity DataIC50: 2.80E+3nMAssay Description:Inhibition of GST-tagged human recombinant EGFR catalytic domain (668 to 1210 amino acids) L858R mutant expressed in Sf9 cells pre-incubated for 30 m...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Technische Universit£T Dortmund

Curated by ChEMBL
LigandPNGBDBM50084037(CHEMBL3425672)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of wild type N-terminal His6-tagged human EGFR kinase domain (702 to 1016 residues) expressed in Sf9 cells pre-incubated for 30 mins befor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/4/2016
Entry Details Article
PubMed