BDBM50086179 CHEMBL17173::N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-2-[4-(2,6-dioxo-1,3-dipropyl-2,3,6,7-tetrahydro-1H-purin-8-yl)-phenoxy]-acetamide

SMILES CCCn1c2nc([nH]c2c(=O)n(CCC)c1=O)-c1ccc(OCC(=O)NN2C(=O)C(C)=C(C)C2=O)cc1

InChI Key InChIKey=NIXWFDNYUWLKLC-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50086179   

TargetAdenosine receptor A1(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50086179(N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)...)
Affinity DataKi:  11.1nMAssay Description:Antagonist activity against adenosine A1 receptor in rat brain membrane in presence of [3H]R-PIA radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50086179(N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)...)
Affinity DataKi:  26.6nMAssay Description:Antagonist activity against human A2B adenosine receptor expressed in HEK293 cells uisng [3H]ZM-241385 or [125I]-IABOPXMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Rat)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50086179(N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)...)
Affinity DataKi:  126nMAssay Description:Antagonist activity against adenosine A2A receptor in rat striatal membrane in presence of [3H]CGS-21680 radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50086179(N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)...)
Affinity DataKi:  670nMAssay Description:Antagonist activity against human adenosine A3 receptor expressed in HEK cells in presence of [125]IAB-MECA or [125I]IABA radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50086179(N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)...)
Affinity DataKi:  1.97E+3nMAssay Description:Antagonist activity against recombinant human adenosine A2A receptor expressed in HEK293 cells in presence of [125I]iodo-ZM-241385 radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
National Institute of Diabetes

Curated by ChEMBL
LigandPNGBDBM50086179(N-(3,4-Dimethyl-2,5-dioxo-2,5-dihydro-pyrrol-1-yl)...)
Affinity DataKi:  3.03E+3nMAssay Description:Antagonist activity against recombinant human adenosine A1 receptor expressed in HEK293 cells in presence of [125I]IABA radioligand.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed