BDBM50086862 6-Chloro-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-8-carboxylic acid ((R)-1-phenethyl-pyrrolidin-2-ylmethyl)-amide::CHEMBL279937

SMILES CN1CCOc2c1cc(Cl)cc2C(=O)NC[C@H]1CCCN1CCc1ccccc1

InChI Key InChIKey=ZIGNSANQGXWXBU-UHFFFAOYSA-N

Data  4 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50086862   

Target5-hydroxytryptamine receptor 1A(Rat)
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50086862(6-Chloro-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine...)
Affinity DataKi:  35nMAssay Description:Inhibitory concentration against binding of 5-hydroxytryptamine 1A receptor from striata of male Wistar rats by displacement of [3H]8-OH-DPATMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Rat)
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50086862(6-Chloro-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine...)
Affinity DataKi:  35nMAssay Description:Ability to displace [3H]-8-OH-DPAT from serotonergic 5-hydroxytryptamine 1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetD(2) dopamine receptor(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM50086862(6-Chloro-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine...)
Affinity DataKi:  57nMAssay Description:Ability to displace [3H]spiperone from D2 dopamine receptor isolated from the striata of male Wistar ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2010
Entry Details Article

TargetD(2) dopamine receptor(Human)
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50086862(6-Chloro-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine...)
Affinity DataKi:  57nMAssay Description:Binding affinity for Dopamine receptor D2 by displacement of [3H]-spiperoneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerotonin 2 (5-HT2) receptor(Rat)
Yoshitomi Pharmaceutical Industries

Curated by ChEMBL
LigandPNGBDBM50086862(6-Chloro-4-methyl-3,4-dihydro-2H-benzo[1,4]oxazine...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory concentration against binding of 5-hydroxytryptamine 2 receptor from striata of male Wistar rats by displacement of [3H]-ketanserinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed