BDBM50087008 8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one::CHEMBL284414

SMILES O=C1NCN(c2ccccc2)C11CCN(CC1)C1CCc2ccccc12

InChI Key InChIKey=FQJXOOHCZZQVHD-UHFFFAOYSA-N

Data  8 KI  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50087008   

TargetNociceptin receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087008(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Affinity DataKi:  0.700nMAssay Description:Competitive binding affinity against transfected HEK293 cells expressing Opioid receptor like 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087008(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Affinity DataKi:  1.20nMAssay Description:Displacement of [125I]nociceptin from human nociceptin receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087008(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Affinity DataKi:  3.40nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor mu 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087008(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Affinity DataKi:  5.30nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor kappa 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetMu-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087008(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Affinity DataKi:  19nMAssay Description:Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetKappa-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087008(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]diprenorphine from human kappa opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087008(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Affinity DataKi:  540nMAssay Description:Competitive binding displacement analyses was performed from permanently transfected HEK293 cells expressing Opioid receptor delta 1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087008(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Affinity DataKi:  1.85E+3nMAssay Description:Displacement of [3H]diprenorphine from human delta opioid receptor expressed in CHO cell membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetNociceptin receptor(Human)
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50087008(8-indan-1-yl-1-phenyl-1,3,8-triaza-spiro[4.5]decan...)
Affinity DataEC50:  7.90E+3nMAssay Description:Effective concentration required to stimulate binding of GTPgammaS to ORL1 receptor was determined using scintillation proximity assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2012
Entry Details Article
PubMed