BDBM50089303 CHEMBL3577925

SMILES Fc1ccc(c(F)c1)S(=O)(=O)Nc1cc(cnc1Cl)-c1cc2c(ncnc2s1)-c1ccncc1

InChI Key InChIKey=OGUIPHCQISNMKY-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50089303   

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50089303(CHEMBL3577925)
Affinity DataIC50: 0.230nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2/PS as substrate after 1 hr by luciferase-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50089303(CHEMBL3577925)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2/PS as substrate after 1 hr by luciferase-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50089303(CHEMBL3577925)
Affinity DataIC50: 3.60nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2/PS as substrate after 1 hr by luciferase-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50089303(CHEMBL3577925)
Affinity DataIC50: 10nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2/PS as substrate after 1 hr by luciferase-based luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Pkucare Pharmaceutical R & D Center

Curated by ChEMBL
LigandPNGBDBM50089303(CHEMBL3577925)
Affinity DataIC50: 54nMAssay Description:Inhibition of mTOR (unknown origin) using GFP-4E-BP1 as substrate after 1 hr by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2016
Entry Details Article
PubMed