BDBM50089511 7,7-Difluoro-3-(4-fluoro-phenyl)-8-methyl-2-propyl-8-aza-bicyclo[3.2.1]octane::CHEMBL286179

SMILES CCCC1C2N(C)C(CC2(F)F)CC1c1ccc(F)cc1

InChI Key InChIKey=ZYGIBURKMBXCNI-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50089511   

TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50089511(7,7-Difluoro-3-(4-fluoro-phenyl)-8-methyl-2-propyl...)
Affinity DataKi:  860nMAssay Description:ability to displace [3H]- Mazindol binding to cocaine binding sites on Dopamine transporter of rat striatal membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50089511(7,7-Difluoro-3-(4-fluoro-phenyl)-8-methyl-2-propyl...)
Affinity DataKi:  1.45E+3nMAssay Description:Compound was tested for its ability to inhibit high affinity uptake of [3H]DA into rat striatal membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50089511(7,7-Difluoro-3-(4-fluoro-phenyl)-8-methyl-2-propyl...)
Affinity DataKi:  3.79E+3nMAssay Description:Compound was tested for its ability to inhibit high-affinity uptake of [3H]NE into parietal and occipital cortex in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Georgetown University Medical Center

Curated by ChEMBL
LigandPNGBDBM50089511(7,7-Difluoro-3-(4-fluoro-phenyl)-8-methyl-2-propyl...)
Affinity DataKi:  7.91E+3nMAssay Description:Compound was tested for its ability to inhibit high affinity uptake of [3H]5-HT into mid brain nerve endings (synaptosomes) in ratMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/1/2012
Entry Details Article
PubMed