BDBM50090038 4-(3,4-Difluoro-phenyl)-2-oxo-6-trifluoromethyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid {3-[4-(2-cyano-4-fluoro-phenyl)-piperidin-1-yl]-propyl}-amide::CHEMBL94259

SMILES Fc1ccc(C2CCN(CCCNC(=O)C3[C@H](NC(=O)N=C3C(F)(F)F)c3ccc(F)c(F)c3)CC2)c(c1)C#N

InChI Key InChIKey=MNHTZNWGEQJHJN-UHFFFAOYSA-N

Data  3 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50090038   

TargetAlpha-1A adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090038(4-(3,4-Difluoro-phenyl)-2-oxo-6-trifluoromethyl-1,...)
Affinity DataKi:  4.20nMAssay Description:Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1A adrenergic receptor stably expressed in CHO cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1B adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090038(4-(3,4-Difluoro-phenyl)-2-oxo-6-trifluoromethyl-1,...)
Affinity DataKi:  200nMAssay Description:Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1B adrenergic receptor stably expressed in LM cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAlpha-1D adrenergic receptor(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50090038(4-(3,4-Difluoro-phenyl)-2-oxo-6-trifluoromethyl-1,...)
Affinity DataKi:  270nMAssay Description:Evaluated for the ability to displace [125I]- HEAT from human cloned Alpha-1D adrenergic receptor stably expressed in HEK cells.More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed