BDBM50091291 CHEMBL3582203

SMILES C[C@H]1C[C@@H](C)CN(Cc2ccc(cc2)-c2cnc3[nH]c4cnc(cc4c3c2)C#N)C1

InChI Key InChIKey=WWFGJJXAAWQFJQ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50091291   

TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091291(CHEMBL3582203)
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human recombinant Chk1 using biotinylated AKT substrate after 30 mins by Alphascreen biochemical assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091291(CHEMBL3582203)
Affinity DataEC50:  209nMAssay Description:Inhibition of CHK1 in human HT29 cells assessed as phosphorylation of histone H3 after 24 hrs by checkpoint abrogation cellular assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed
TargetAcetylcholinesterase(Human)
Argenta Discovery

Curated by ChEMBL
LigandPNGBDBM50091291(CHEMBL3582203)
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human acetylcholine esterase by horseradish peroxidase-coupled fluorescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/10/2016
Entry Details Article
PubMed