BDBM50092879 2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,5-bis-trifluoromethyl-phenyl)-amide::CHEMBL132495

SMILES Cc1nc(Cl)ncc1C(=O)Nc1cc(cc(c1)C(F)(F)F)C(F)(F)F

InChI Key InChIKey=VORNGVYSIPQDMN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50092879   

TargetTranscription factor Jun(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50092879(2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,...)
Affinity DataIC50: 20nMAssay Description:Inhibition of AP-1-mediated transcriptional activation in human Jurkat cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2016
Entry Details Article
PubMed
TargetTranscription factor Jun(Human)
University of Texas Medical Branch

Curated by ChEMBL
LigandPNGBDBM50092879(2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,...)
Affinity DataIC50: 20nMAssay Description:Concentration required to inhibit activator protein-1(AP-1) mediated transcriptional activation in human Jurkat T-cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetExportin-1(Human)
Case Western Reserve University

Curated by ChEMBL
LigandPNGBDBM50092879(2-Chloro-4-methyl-pyrimidine-5-carboxylic acid (3,...)
Affinity DataEC50:  4.09E+3nMAssay Description:Inhibition of XPO1 in human Jurkat cells assessed as suppression of IL-2 expression incubated for 6 hrs by Bright-Glo Luciferase based microplate rea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMed