BDBM50093187 1,5-di{4-[4-amino(imino)methylbenzylcarbamoyl]hexahydro-1-pyrazinylcarbonyloxy}cyclooctane::CHEMBL298256::Derivative of piperazine-1-carboxylic acid 5-(piperazine-1-carbonyloxy)-cyclooctyl ester

SMILES NC(=N)c1ccc(CNC(=O)N2CCN(CC2)C(=O)O[C@H]2CCC[C@H](CCC2)OC(=O)N2CCN(CC2)C(=O)NCc2ccc(cc2)C(N)=N)cc1

InChI Key InChIKey=FACNOXIVXQYGTJ-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50093187   

TargetTryptase beta-2/delta/gamma(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093187(Derivative of piperazine-1-carboxylic acid 5-(pipe...)
Affinity DataKi:  8.70nMAssay Description:Inhibition of Tryptase in human mast cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTryptase beta-2/delta/gamma(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093187(Derivative of piperazine-1-carboxylic acid 5-(pipe...)
Affinity DataKi:  9nMAssay Description:Evaluated for its inhibitory potency against tryptaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine protease 1(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093187(Derivative of piperazine-1-carboxylic acid 5-(pipe...)
Affinity DataKi:  2.50E+4nMAssay Description:Compound was evaluated for its inhibitory potency against trypsinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTrypsin(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093187(Derivative of piperazine-1-carboxylic acid 5-(pipe...)
Affinity DataKi:  2.50E+4nMAssay Description:Inhibition of trypsin in human mast cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093187(Derivative of piperazine-1-carboxylic acid 5-(pipe...)
Affinity DataKi:  5.95E+4nMAssay Description:Inhibition of thrombin in human mast cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProthrombin(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093187(Derivative of piperazine-1-carboxylic acid 5-(pipe...)
Affinity DataKi:  6.00E+4nMAssay Description:Compound was evaluated for its inhibitory potency against thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093187(Derivative of piperazine-1-carboxylic acid 5-(pipe...)
Affinity DataKi:  1.34E+5nMAssay Description:Compound was evaluated for its inhibitory potency against plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetPlasminogen(Human)
Axys Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50093187(Derivative of piperazine-1-carboxylic acid 5-(pipe...)
Affinity DataKi:  1.34E+5nMAssay Description:Inhibition plasmin in human mast cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed