BDBM50094476 CHEMBL3590222

SMILES CN(C)CC(=O)N1CCC(CC1)c1nc(-c2cnc(N)c(n2)-n2nnc3ccccc23)n(C)n1

InChI Key InChIKey=PISLKDKFKGFUHQ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50094476   

LigandPNGBDBM50094476(CHEMBL3590222)
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human PI3Kdelta using PIP2/ATP as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094476(CHEMBL3590222)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human PI3Kalpha using PIP2/ATP as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094476(CHEMBL3590222)
Affinity DataIC50: 270nMAssay Description:Inhibition of PI3Kalpha in human BT474 cells assessed as inhibition of Akt phosphorylation at Tyr-308 after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094476(CHEMBL3590222)
Affinity DataIC50: 650nMAssay Description:Inhibition of recombinant human PI3Kgamma using PIP2/ATP as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094476(CHEMBL3590222)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human PI3Kbeta using PIP2/ATP as substrate preincubated for 20 mins followed by substrate addition measured after 80 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
LigandPNGBDBM50094476(CHEMBL3590222)
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of PI3Kbeta in human MDA-MB-468 cells assessed as inhibition of Akt phosphorylation at Ser-473 after 2 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50094476(CHEMBL3590222)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase mTOR(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50094476(CHEMBL3590222)
Affinity DataIC50: 2.10E+4nMAssay Description:Inhibition of m-TOR (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/15/2016
Entry Details Article
PubMed