BDBM50095273 (6,7-Diethoxy-quinazolin-4-yl)-(3-iodo-phenyl)-amine::CHEMBL1204262::CHEMBL65704

SMILES CCOc1cc2ncnc(Nc3cccc(I)c3)c2cc1OCC

InChI Key InChIKey=JFCHPYHJJFGZSB-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50095273   

TargetEpidermal growth factor receptor(Human)
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM50095273(CHEMBL1204262 | CHEMBL65704 | (6,7-Diethoxy-quinaz...)
Affinity DataIC50: 0.640nMAssay Description:Displacement of [125I]4-(3-iodoanilino)-6,7-dimethoxyquinazoline from EGFR tyrosine kinase in human A431 cell membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM50095273(CHEMBL1204262 | CHEMBL65704 | (6,7-Diethoxy-quinaz...)
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human EGFR tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-4(Human)
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM50095273(CHEMBL1204262 | CHEMBL65704 | (6,7-Diethoxy-quinaz...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human ErbB4 tyrosine kinase phosphorylation expressed in human CEM/4 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Lawrence Berkeley National Laboratory

Curated by ChEMBL
LigandPNGBDBM50095273(CHEMBL1204262 | CHEMBL65704 | (6,7-Diethoxy-quinaz...)
Affinity DataIC50: 69nMAssay Description:Inhibition of human ErbB2 tyrosine kinase phosphorylation expressed in mouse BaF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed
TargetFructose-1,6-bisphosphatase 1(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50095273(CHEMBL1204262 | CHEMBL65704 | (6,7-Diethoxy-quinaz...)
Affinity DataIC50: 2.10E+3nMAssay Description:Concentration required to inhibit the human liver recombinant fructose-1,6-bisphosphatase.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/3/2012
Entry Details Article
PubMed