BDBM50095488 1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile::CHEMBL8517

SMILES N#CN1Cc2cc3ccccc3nc2C1

InChI Key InChIKey=KLQYVOXLSMHROZ-UHFFFAOYSA-N

Data  1 KI  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50095488   

TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataIC50: 280nMpH: 7.0Assay Description:Inhibition of Cathepsin K at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataIC50: 340nMpH: 5.5Assay Description:Inhibition of Cathepsin K at pH 5.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataIC50: 360nMpH: 5.5Assay Description:Effect of 10 mM of GSH on the inhibitory activity of compound against Cathepsin K, at pH 5.5More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataIC50: 360nMAssay Description:Inhibitory activity tested against Human Cathepsin K receptor using gelatinase assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataIC50: 370nMAssay Description:Inhibitory constant against human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataIC50: 370nMAssay Description:Inhibitory activity tested against Human Cathepsin K using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataKi:  380nMAssay Description:Inhibitory constant against human cathepsin KMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProcathepsin L(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataIC50: 450nMAssay Description:Inhibitory activity tested against Human Cathepsin L using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin B(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibitory activity tested against Human Cathepsin B using Z-Phe-Arg-pNA as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCathepsin K(Human)
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50095488(1,3-Dihydro-pyrrolo[3,4-b]quinoline-2-carbonitrile...)
Affinity DataIC50: 1.14E+4nMpH: 7.0Assay Description:Effect of 10 mM of GSH on the inhibitory activity against Cathepsin K, at pH 7More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed