BDBM50099410 CHEMBL3342849

SMILES CC(C)C(=O)NCc1ccc(Cl)c(c1)-c1nc2cc(ncc2c(=O)[nH]1)-c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=SXZOHBBSSIEDDY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50099410   

TargetProstaglandin E synthase(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50099410BDBM50099410(CHEMBL3342849 | US12465588, Compound GRC27864)
Affinity DataIC50: 4.63nMAssay Description:A test compound or DMSO was added to a protein and a reaction buffer (0.1 M potassium phosphate buffer, 2.5 mM GSH) to make a total volume of 100 μL ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/2/2026
Entry Details

TargetProstaglandin E synthase(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50099410BDBM50099410(CHEMBL3342849 | US12465588, Compound GRC27864)
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant mPGES-1 expressed in CHO cells using PGH2 as substrate incubated for 10 mins prior to substrate addition measured aft...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50099410BDBM50099410(CHEMBL3342849 | US12465588, Compound GRC27864)
Affinity DataIC50: 5nMAssay Description:Inhibition of mPGES-1 in human A549 cells assessed as inhibition of IL-1beta-induced PGE2 production incubated for 30 mins prior to IL-1beta challeng...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Dog)
Glenmark Pharmaceuticals

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50099410BDBM50099410(CHEMBL3342849 | US12465588, Compound GRC27864)
Affinity DataIC50: 154nMAssay Description:Inhibition of mPGES-1 in dog whole blood assessed as inhibition of LPS-induced PGE2 production after overnight incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed
TargetProstaglandin E synthase(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50099410BDBM50099410(CHEMBL3342849 | US12465588, Compound GRC27864)
Affinity DataIC50: 376nMAssay Description:Inhibition of mPGES-1 in human whole blood assessed as inhibition of LPS-induced PGE2 production after overnight incubationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/9/2016
Entry Details Article
PubMed