BDBM50099975 4-(4-Cyclohexyloxy-phenylamino)-6-methoxy-7-(3-morpholin-4-yl-propoxy)-quinoline-3-carbonitrile::CHEMBL31149

SMILES COc1cc2c(Nc3ccc(OC4CCCCC4)cc3)c(cnc2cc1OCCCN1CCOCC1)C#N

InChI Key InChIKey=TVRSCCKYOHTFCB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50099975   

TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099975(4-(4-Cyclohexyloxy-phenylamino)-6-methoxy-7-(3-mor...)
Affinity DataIC50: 110nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using coupled MEK assay (which uses activated Raf to activate an...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50099975(4-(4-Cyclohexyloxy-phenylamino)-6-methoxy-7-(3-mor...)
Affinity DataIC50: 320nMAssay Description:Inhibitory activity against Dual specificity mitogen-activated protein kinase kinase using direct MEK assay (which by-passes the need for activated R...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed