BDBM50100021 (S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-phenyl)-propionic acid methyl ester::CHEMBL33227

SMILES COC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c1cccc2ccccc12

InChI Key InChIKey=VMFGCGRAIBLAFY-UHFFFAOYSA-N

Data  11 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50100021   

TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 5nMAssay Description:Antagonist activity against C-C chemokine receptor type 3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 5nMAssay Description:Inhibitory activity against human eosinophil C-C chemokine receptor type 3 using [125I]- human eotaxin as the radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 5nMAssay Description:Binding affinity was determined towards C-C chemokine receptor type 3 using [125I]-labeled eotaxin as radioligandMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/8/2012
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 7nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing [125I]-MCP-4 radioligand,using CCR3 binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 25nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using Esonophil chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 32nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using Esonophil chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 32nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using Esonophil chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 35nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand,using [Ca2+] mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 35nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin-2 radioligand,using [Ca2+] mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 38nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing Eotaxin radioligand,using [Ca2+] mobilization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataIC50: 330nMAssay Description:Agonistic activity of the compound against C-C chemokine receptor type 3 by displacing MCP-4 radioligand,using Esonophil chemotaxis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetC-C chemokine receptor type 3(Human)
Smithkline Beecham Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50100021((S)-2-[(Naphthalene-1-carbonyl)-amino]-3-(4-nitro-...)
Affinity DataEC50:  780nMAssay Description:Antagonist activity at human EGFP-fused CCR3 expressed in mouse L1.2 cells assessed as inhibition of CCL11-induced chemotaxis measured after 1.5 hrs ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/4/2018
Entry Details Article
PubMed