BDBM50100305 2-(2,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-benzonitrile::CHEMBL22319

SMILES Clc1ccc(Oc2cc(Cn3ccnc3)ccc2C#N)c(Cl)c1

InChI Key InChIKey=CKUAWXYQQWMTHM-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50100305   

LigandPNGBDBM50100305(2-(2,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Affinity DataIC50:  280nMAssay Description:Inhibition of rate of incorporation of [3H]-GGPP into a biotinylated peptide corresponding to C-terminus of human Ki-Ras by human geranylgeranyl-tran...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100305(2-(2,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Affinity DataIC50:  8nMAssay Description:Inhibition of rate of incorporation of [3H]-FPP into recombinant Ras-CVIM by human farnesyltransferase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50100305(2-(2,4-Dichloro-phenoxy)-4-imidazol-1-ylmethyl-ben...)
Affinity DataIC50:  260nMAssay Description:Displacement of radiolabeled FTI from Farnesyltransferase in cultured v-Ha-ras-transformed RAT1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed