BDBM50103356 (3-{(1-Benzyl-2-oxo-pyrrolidin-3-yl)-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethyl]-amino}-propyl)-carbamic acid tert-butyl ester::(S)-tert-butyl 3-((1-benzyl-2-oxopyrrolidin-3-yl)((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methyl)amino)propylcarbamate::CHEMBL98553

SMILES CC(C)(C)OC(=O)NCCCN(Cc1cncn1Cc1ccc(cc1)C#N)[C@H]1CCN(Cc2ccccc2)C1=O

InChI Key InChIKey=SLYBJCUKCICSBD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50103356   

TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103356((3-{(1-Benzyl-2-oxo-pyrrolidin-3-yl)-[3-(4-cyano-b...)
Affinity DataIC50: 18nMAssay Description:In vitro inhibition of farnesyl transferase using purified recombinant human enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDimer of Protein farnesyltransferase subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103356((3-{(1-Benzyl-2-oxo-pyrrolidin-3-yl)-[3-(4-cyano-b...)
Affinity DataIC50: 65nMAssay Description:Concentration required to displace 50% of a potent radiolabeled FTI from farnesyl transferase in cultured H-ras-transformed Rat1 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50103356((3-{(1-Benzyl-2-oxo-pyrrolidin-3-yl)-[3-(4-cyano-b...)
Affinity DataIC50: 110nMAssay Description:Inhibition of human ERG channelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/23/2012
Entry Details Article
PubMed
TargetGeranylgeranyl transferase type-1 subunit beta(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103356((3-{(1-Benzyl-2-oxo-pyrrolidin-3-yl)-[3-(4-cyano-b...)
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibitory concentration of geranylgeranyl-protein transferase type IMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed