BDBM50109459 1-(2-Chloro-phenyl)-3-(2-furan-2-yl-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)-urea::1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-yl)urea::CHEMBL164281

SMILES Cn1cc2c(n1)nc(NC(=O)Nc1ccccc1Cl)n1nc(nc21)-c1ccco1

InChI Key InChIKey=ICNNXGJLOCFASJ-UHFFFAOYSA-N

Data  9 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50109459   

TargetAdenosine receptor A3(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity to human adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/1/2020
Entry Details Article

TargetAdenosine receptor A3(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataKi:  0.910nMAssay Description:Displacement of [3H]MRE3008-F20 binding at human Adenosine A3 receptor expressed in HEK cells; range 0.82-1.01More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataKi:  0.910nMAssay Description:Displacement of [3H]NECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataKi:  0.910nMAssay Description:Binding affinity for human adenosine A3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataIC50: 8.20nMAssay Description:Inhibition of IB-MECA agonist-mediated cAMP production in CHO cell membranes expressing human Adenosine A3 receptor; range 4.4-15.2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataKi:  101nMAssay Description:Displacement of [3H]DPCPX from human Adenosine A2B receptor expressed in HEK293 cells; range 89-116More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Padova

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/29/2010
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Padova

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]SCH-58261 from human Adenosine A2A receptor expressed in HEK293 cells; range 174-230More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
Università

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataKi:  400nMAssay Description:Displacement of [3H]DPCPX from human Adenosine A1 receptor expressed in CHO cells; range 332-479More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)TBA
LigandChemical structure of BindingDB Monomer ID 50109459BDBM50109459(1-(2-chlorophenyl)-3-(2-(furan-2-yl)-8-methyl-8H-p...)
Affinity DataKi:  912nMAssay Description:Displacement of [3H]MRE3008-F20 from human adenosine A3 receptor expressed in CHO cells after 120 minsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2013
Entry Details Article
PubMed