BDBM50117772 CHEMBL10921::N-(2-Diethylamino-ethyl)-2-[2-(4-fluoro-benzylsulfanyl)-5-(1-methyl-1H-pyrazol-4-ylmethyl)-4-oxo-4H-pyrimidin-1-yl]-N-(4'-trifluoromethyl-biphenyl-4-ylmethyl)-acetamide
SMILES CCN(CC)CCN(Cc1ccc(cc1)-c1ccc(cc1)C(F)(F)F)C(=O)Cn1cc(Cc2cnn(C)c2)c(=O)nc1SCc1ccc(F)cc1
InChI Key InChIKey=VGIQUSQBXZXBGW-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 11 hits for monomerid = 50117772
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataKi: 0.0300nMAssay Description:Steady state and transient kinetics to a freely reversible, non-covalently bound, human recombinant Phospholipase A2 (rhLp-PLA2) was determinedMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:CInhibition of cytochrome P450 2D6More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of cytochrome P450 2C9More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of cytochrome P450 1A2More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) was estimatedMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibitory activity against Cytochrome P450 2D6More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibitory activity against CYP450 3A4 isozymeMore data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.0600nMAssay Description:Inhibitory activity against recombinant human Lp-PLA2More data for this Ligand-Target Pair
TargetPlatelet-activating factor acetylhydrolase(Homo sapiens (Human))
Glaxosmithkline
Curated by ChEMBL
Glaxosmithkline
Curated by ChEMBL
Affinity DataIC50: 0.00600nMAssay Description:Inhibition of the Phospholipase A2 (Lp-PLA2) enzyme in whole human plasmaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of cytochrome P450 3A4More data for this Ligand-Target Pair
Affinity DataIC50: >4.00E+4nMAssay Description:Inhibition of cytochrome P450 2C19More data for this Ligand-Target Pair