BDBM50124419 CHEMBL172297::Thiophene-2-sulfonic acid {3-[6-(4-tert-butyl-benzenesulfonylamino)-2-cyclopropyl-5-(2-methoxy-phenoxy)-pyrimidin-4-yloxy]-propyl}-amide

SMILES COc1ccccc1Oc1c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)nc(nc1OCCCNS(=O)(=O)c1cccs1)C1CC1

InChI Key InChIKey=BCRJIIJVFJJYRD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50124419   

TargetEndothelin-1 receptor(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50124419(CHEMBL172297 | Thiophene-2-sulfonic acid {3-[6-(4-...)
Affinity DataIC50:  14nMAssay Description:Inhibitory concentration required against [125I]-ET-1 binding to membranes of CHO cells expressing human ETA receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEndothelin receptor type B(Homo sapiens (Human))
Actelion Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50124419(CHEMBL172297 | Thiophene-2-sulfonic acid {3-[6-(4-...)
Affinity DataIC50:  2nMAssay Description:Inhibitory concentration required against [125I]-ET-1 binding to membranes of CHO cells expressing human ETB receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed