BDBM50124537 2-Cyclobutyl-5-fluoro-1,2-dihydro-quinazolin-4-ylamine::CHEMBL352659

SMILES NC1=NC(Nc2cccc(F)c12)C1CCC1

InChI Key InChIKey=TWDKMKHCHFFGDT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50124537   

TargetNitric oxide synthase, inducible(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124537(2-Cyclobutyl-5-fluoro-1,2-dihydro-quinazolin-4-yla...)
Affinity DataIC50: 20nMAssay Description:Inhibitory activity of compound against human inducible nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, brain(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124537(2-Cyclobutyl-5-fluoro-1,2-dihydro-quinazolin-4-yla...)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibitory activity against human neuronal nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetNitric oxide synthase, endothelial(Human)
Astrazeneca R&D Charnwood

Curated by ChEMBL
LigandPNGBDBM50124537(2-Cyclobutyl-5-fluoro-1,2-dihydro-quinazolin-4-yla...)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibitory activity against human endothelial nitric oxide synthaseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed