BDBM50125981 CHEMBL3627901::US10189819, Example 113

SMILES Cc1ncn(n1)-c1cc(Cl)c(C(=O)NC[C@@H](c2cccc(F)c2)c2ccc3c(C)ccc(F)c3n2)c(Cl)c1

InChI Key InChIKey=FVHANSCTSMEQER-NRFANRHFSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50125981   

TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50125981(CHEMBL3627901 | US10189819, Example 113)
Affinity DataKi:  10nMAssay Description:Inhibition of human coagulation factor 9a using fluorescent peptide CH3SO2-D-CHG-Gly-Arg-AFC-AcoH as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50125981(CHEMBL3627901 | US10189819, Example 113)
Affinity DataKi: >2.89E+4nMAssay Description:Inhibition of human coagulation factor 10a using fluorescent peptide nAcetyl-KPR-AFC as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor IX(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50125981(CHEMBL3627901 | US10189819, Example 113)
Affinity DataIC50:  10.4nMAssay Description:Formation of a clot to stem bleeding at a site of blood vessel injury involves the coordinated activity of a group of plasma proteins that initiate a...More data for this Ligand-Target Pair
In DepthDetails US Patent