BDBM50128339 CHEMBL3629172

SMILES N#Cc1ccnc(Nc2cc(C3CCOC3)n(n2)C2CCCC2)c1

InChI Key InChIKey=ZBHXJFIKXIBKBY-UHFFFAOYSA-N

Data  1 KI  1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50128339   

TargetMitogen-activated protein kinase kinase kinase 12(Human)
Wuxi Apptec

Curated by ChEMBL

LigandBDBM50128339(CHEMBL3629172)Copy SMILESCopy InChI

Affinity DataKi:  54nMAssay Description:Inhibition of N-terminally GST- tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminally HIS-tagged MKK4 K131M as substrate incuba...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/15/2016
Entry Details Article
Copy BDB DOIPubMed
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TargetMitogen-activated protein kinase kinase kinase 12(Human)
Wuxi Apptec

Curated by ChEMBL

LigandBDBM50128339(CHEMBL3629172)Copy SMILESCopy InChI

Affinity DataIC50: 698nMAssay Description:Inhibition of Dox inducible human DLK transfected in HEK293 cells assessed as reduction in JNK phosphorylation incubated for 5.5 hrs measured by Hoec...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
12/15/2016
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL