BDBM50128534 5-(4,11-Dimethyl-1,2,4,11-tetrahydro-pyrido[4,3-a]carbazol-3-ylmethyl)-pyrimidine-2,4-diamine::CHEMBL308758

SMILES CC1N(Cc2cnc(N)nc2N)CCc2c1ccc1c3ccccc3n(C)c21

InChI Key InChIKey=KZNVWZDVHNNDIM-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50128534   

TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128534(5-(4,11-Dimethyl-1,2,4,11-tetrahydro-pyrido[4,3-a]...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Staphylococcus aureus (strain MW2))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128534(5-(4,11-Dimethyl-1,2,4,11-tetrahydro-pyrido[4,3-a]...)
Affinity DataIC50:  6.80E+3nMAssay Description:Inhibitory activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus aureus 157/4696More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128534(5-(4,11-Dimethyl-1,2,4,11-tetrahydro-pyrido[4,3-a]...)
Affinity DataIC50:  4nMAssay Description:Antibacterial activity of TMP-susceptible Dihydrofolate reductase against Staphylococcus pneumoniae ATCC 49619More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
F. Hoffmann-La Roche

Curated by ChEMBL
LigandPNGBDBM50128534(5-(4,11-Dimethyl-1,2,4,11-tetrahydro-pyrido[4,3-a]...)
Affinity DataIC50:  85nMAssay Description:Antibacterial activity against TMP-Resistance Dihydrofolate reductase from Staphylococcus pneumoniae 1/1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed