BDBM50130348 (2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylate::3-[Bis-(4-fluoro-phenyl)-methoxy]-8-methyl-8-aza-bicyclo[3.2.1]octane-2-carboxylic acid ethyl ester::CHEMBL317362

SMILES CCOC(=O)[C@@H]1C2CCC(C[C@@H]1OC(c1ccc(F)cc1)c1ccc(F)cc1)N2C

InChI Key

Data  8 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50130348   

TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataIC50: 1.80nMAssay Description:In vitro potency for inhibiting [3H]- dopamine uptake was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataIC50: 1.80nMAssay Description:Inhibition of [3H]dopamine uptake at DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataKi:  6.87nMAssay Description:Displacement of [3H]WIN-35428 from DAT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataKi:  16.4nMAssay Description:In vitro dopamine transporter binding affinity using [3H]WIN-35428 as radioligand was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataKi:  629nMAssay Description:Binding affinity towards norepinephrine transporter using [3H]nisoxetine as radioligand was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataKi:  629nMAssay Description:Displacement of [3H]nisoxetine from NET in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataKi:  1.85E+3nMAssay Description:Binding affinity towards serotonin transporter using [3H]citalopram as radioligand was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
National Institute On Drug Abuse

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataKi:  1.85E+3nMAssay Description:Displacement of [3H]citalopram from SERT in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataKi:  1.89E+3nMAssay Description:Displacement of [3H]pirenzepine from M1 receptor in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/8/2012
Entry Details Article
PubMed
TargetMuscarinic acetylcholine receptor M1(Rat)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50130348((2R,3S)-ethyl 3-(bis(4-fluorophenyl)methoxy)-8-met...)
Affinity DataKi:  1.89E+3nMAssay Description:Binding affinity towards Muscarinic acetylcholine receptor M1 using [3H]pirenzepine as radioligand was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed