BDBM50131367 7,8-Dimethoxy-3-(4-quinolin-6-ylmethyl-piperazin-1-ylmethyl)-3a,4-dihydro-3H-chromeno[4,3-c]isoxazole::CHEMBL90966

SMILES COc1cc2OCC3C(CN4CCN(Cc5ccc6ncccc6c5)CC4)ON=C3c2cc1OC

InChI Key InChIKey=APNJYYQXBHETAR-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50131367   

TargetSodium-dependent serotonin transporter(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131367(7,8-Dimethoxy-3-(4-quinolin-6-ylmethyl-piperazin-1...)
Affinity DataKi:  8.10nMAssay Description:In vitro binding affinity towards rat serotonin transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131367(7,8-Dimethoxy-3-(4-quinolin-6-ylmethyl-piperazin-1...)
Affinity DataKi:  36nMAssay Description:In vitro binding affinity towards human adrenergic alpha-2C adrenergic receptor using [3H]-rauwolscineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131367(7,8-Dimethoxy-3-(4-quinolin-6-ylmethyl-piperazin-1...)
Affinity DataKi:  117nMAssay Description:In vitro binding affinity towards human alpha-2A adrenergic receptor using [3H]-rauwolscineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50131367(7,8-Dimethoxy-3-(4-quinolin-6-ylmethyl-piperazin-1...)
Affinity DataKi:  721nMAssay Description:In vitro binding affinity towards human alpha-2B adrenergic receptor using [3H]-rauwolscineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed