BDBM50132976 2-[4-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-pyridine::CHEMBL125846

SMILES Cc1cccc(n1)-c1n[nH]cc1-c1ccc(F)cc1

InChI Key InChIKey=VJPFFCRCUZQGJL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50132976   

TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132976(2-[4-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50: 41nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132976(2-[4-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50: 70nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132976(2-[4-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50: 139nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50132976(2-[4-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)
Affinity DataIC50: 2.00E+4nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed