BDBM50136277 (3R,4S)-Piperidine-3,4-dicarboxylic acid 3-hydroxyamide 4-{[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-amide}::CHEMBL137297

SMILES Cc1cc(COc2ccc(NC(=O)[C@H]3CCNC[C@@H]3C(=O)NO)cc2)c2ccccc2n1

InChI Key InChIKey=VVYSJNRLNVGHLZ-UHFFFAOYSA-N

Data  3 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50136277   

TargetDisintegrin and metalloproteinase domain-containing protein 17(Pig)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136277((3R,4S)-Piperidine-3,4-dicarboxylic acid 3-hydroxy...)
Affinity DataIC50: 1.5nMAssay Description:In vitro binding affinity against porcine TACEMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136277((3R,4S)-Piperidine-3,4-dicarboxylic acid 3-hydroxy...)
Affinity DataKi: >2.13E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-9 (MMP-9)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target72 kDa type IV collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136277((3R,4S)-Piperidine-3,4-dicarboxylic acid 3-hydroxy...)
Affinity DataKi: >3.33E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-2 (MMP-2)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50136277((3R,4S)-Piperidine-3,4-dicarboxylic acid 3-hydroxy...)
Affinity DataKi: >4.95E+3nMAssay Description:Inhibitory activity against matrix metalloprotease-1 (MMP-1)More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed