BDBM50136514 (3R,4S)-4-Phenyl-piperidine-3-carboxylic acid {(R)-3-[6-(4-chloro-phenylsulfanyl)-2-(4-methoxy-phenyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-1-methyl-propyl}-amide; hydrochloride::CHEMBL188146::CHEMBL539306

SMILES COc1ccc(cc1)-n1nc(Sc2ccc(Cl)cc2)cc(CC[C@@H](C)NC(=O)[C@H]2CNCC[C@@H]2c2ccccc2)c1=O

InChI Key InChIKey=LQUHPSCNOVBDIJ-UHFFFAOYSA-N

Data  4 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50136514   

TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50136514(CHEMBL539306 | CHEMBL188146 | (3R,4S)-4-Phenyl-pip...)
Affinity DataIC50: 33nMAssay Description:Concentration required to inhibit binding of [125I]-NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-4-rece...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50136514(CHEMBL539306 | CHEMBL188146 | (3R,4S)-4-Phenyl-pip...)
Affinity DataIC50: 33nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50136514(CHEMBL539306 | CHEMBL188146 | (3R,4S)-4-Phenyl-pip...)
Affinity DataEC50:  177nMAssay Description:Effective concentration for cAMP accumulation relative to alpha-MSH at human MC4RMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50136514(CHEMBL539306 | CHEMBL188146 | (3R,4S)-4-Phenyl-pip...)
Affinity DataEC50:  180nMAssay Description:Effective concentration at human melanocortin 4 receptor in cAMP release assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanocortin receptor 5(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50136514(CHEMBL539306 | CHEMBL188146 | (3R,4S)-4-Phenyl-pip...)
Affinity DataIC50: 1.41E+3nMAssay Description:Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-5-recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed
TargetMelanocortin receptor 3(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50136514(CHEMBL539306 | CHEMBL188146 | (3R,4S)-4-Phenyl-pip...)
Affinity DataIC50: 2.17E+3nMAssay Description:Concentration required to inhibit binding of [125I]NDP-alpha-MSH from membranes prepared from CHO cells expressing human melanocortin subtype-3-recep...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/9/2012
Entry Details Article
PubMed