BDBM50139308 (R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenoxy)-propyl]-piperazin-1-yl}-propan-1-one::CHEMBL302196

SMILES C[C@@H](N)C(=O)N1CCN(CCCOc2ccc(cc2)C(=O)C2CC2)CC1

InChI Key InChIKey=KPXVCGPCRXEDLT-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50139308   

TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards Histamine H3 receptor of rat cortical membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  2.5nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing rat histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Rat)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  2.51nMAssay Description:Binding affinity to rat cortical histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  760nMAssay Description:Binding affinity for human histamine H3 receptor on human colon cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  760nMAssay Description:In vitro binding affinity was determined as displacement of [3H]N-R-methylhistamine from C6 cell membranes expressing human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/3/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  794nMAssay Description:Binding affinity to human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetHistamine H1 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  6.92E+4nMAssay Description:Binding affinity towards Histamine H1 receptor of human membranes.More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed
TargetHistamine H2 receptor(Human)
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50139308((R)-2-Amino-1-{4-[3-(4-cyclopropanecarbonyl-phenox...)
Affinity DataKi:  7.08E+4nMAssay Description:Binding affinity towards Histamine H2 receptor from human membranesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/19/2013
Entry Details Article
PubMed