BDBM50139373 CHEMBL3763823

SMILES Cn1ncc2CN(C(=O)CCCCCCCN3CCN(Cc4cc(O)cc(O)c4)CC3)c3ccccc3Nc12

InChI Key InChIKey=PBYCSFCOYVZDBM-UHFFFAOYSA-N

Data  4 KI  4 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50139373   

TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]-vasopressin from human vasopressin V1a receptor expressed in HEK293 cell membranes after 90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataKi:  64nMAssay Description:Displacement of [3H]-vasopressin from human vasopressin 1a receptor expressed in HEK293 cells after 90 mins by microbeta 2 microplate-reader methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataIC50: 4.67E+3nMAssay Description:Antagonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin-induced IP1 accumulation preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataIC50: 4.67E+3nMAssay Description:Antagonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as inhibition of vasopressin induced IP1 accumulation pretrea...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataKi:  8.35E+3nMAssay Description:Displacement of [3H]-oxytocin from human oxytocin receptor expressed in HEK293 cells after 90 mins by microbeta 2 microplate reader analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataKi:  8.35E+3nMAssay Description:Displacement of [3H]-oxytocin from human OTR expressed in HEK293 cell membranes after 90 mins by radioligand binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human vasopressin 1a receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetVasopressin V1a receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human vasopressin V1a receptor expressed in HEK293 cells assessed as induction of IP1 accumulation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human oxytocin receptor expressed in HEK293 cells assessed as inhibition of oxytocin induced IP1 accumulation pretreated for 3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human oxytocin receptor expressed in HEK293 cells assessed as increase in IP1 accumulation preincubated for 1 hr followed by addi...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2017
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at human OTR expressed in HEK293 cells assessed as inhibition of agonist-induced IP1 accumulation preincubated for 30 mins follow...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed
TargetOxytocin receptor(Human)
The University of Sydney

Curated by ChEMBL
LigandPNGBDBM50139373(CHEMBL3763823)
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human OTR expressed in HEK293 cells assessed as induction of IP1 accumulation after 1 hr by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/8/2020
Entry Details Article
PubMed