BDBM50140533 CHEMBL25211::N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-cyclohexyl]-4-trifluoromethoxy-benzenesulfonamide

SMILES N[C@@H]([C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc(OC(F)(F)F)cc1)C(=O)N1CCSC1

InChI Key InChIKey=IEFYZYNWWLPCJV-UHFFFAOYSA-N

Data  1 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50140533   

TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50140533(N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50: 22nMAssay Description:Inhibition of DPP4More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50140533(N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50: 22nMAssay Description:Inhibitory activity against human Dipeptidylpeptidase IVMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 8(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50140533(N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50: 930nMAssay Description:Inhibition of DPP8More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50140533(N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibitory activity against human quiescent cell proline dipeptidase (QPP) enzymeMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDipeptidyl peptidase 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50140533(N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of QPPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetDipeptidyl peptidase 9(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50140533(N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of DPP9More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50140533(N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataKi:  2.80E+3nMAssay Description:Binding affinity towards human ERG potassium ion channel was determinedMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProlyl endopeptidase FAP(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50140533(N-[4-((S)-1-Amino-2-oxo-2-thiazolidin-3-yl-ethyl)-...)
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of FAPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/24/2011
Entry Details Article
PubMed